U.S. Department of Health and Human ServicesHHS National Institutes of HealthNIH National Center for Advancing Translational SciencesNCATS

Jobs

Bioinformatician, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Chemical Genomics Branch
Stem Cell Translation Laboratory
Rockville, Maryland

Description

NCATS, a major research component of the NIH, seeks applications from qualified candidates to fill a bioinformatician in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the Center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as induced pluripotent stem cells, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D/3-D cell culture systems.

The successful candidate will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS and collaborators at top-academic institutions.

Core Responsibilities

Computational analysis is integral to the lab’s efforts in the deep characterization of stem cell states and functional cell types from different developmental lineages. The bioinformatician will be required to promptly turn around analysis results to respond to biologists’ ongoing projects, work on multiple projects in parallel and coordinate/oversee data analysis with external service providers.

Qualifications

Applicants should have a master’s degree or higher in bioinformatics, computational biology or biomedical data science. The ideal candidate should have strong science communication skills, clear and effective data visualization skills, the ability to work well independently and in a team environment, creative problem-solving skills, and a proven ability to apply cutting-edge, rigorous standards of the bioinformatics fields. Applicants should possess a solid knowledge of R statistical programming language, familiarity with the handling, management, and storage of large-scale sequencing data, and experience querying public databases, including the SRA, GEO, and dbGaP.

Preferred qualifications include experience with next-generation sequencing methods on Illumina and 10x Genomics platforms (e.g., bulk and single-cell RNA-Seq, ChIP-seq methods such as MeDIP-seq, bulk and single-cell ATAC-seq, and miRNA-seq). Experience with other omics, such as WES, WGS, and targeted sequencing methods, are a plus. The ideal candidate will have experience with pre-processing tools for alignment, counting or sequence analysis (e.g., Cell Ranger, STAR, HTSeq, featureCounts, salmon, GATK, etc.) and R packages designed for the above-mentioned methods (e.g., DESeq2, limma, Seurat, etc.). A solid understanding of clustering and dimensionality reduction techniques for big genomic datasets, experience with Python programming, and familiarity with Linux BASH scripting, which is necessary for proper utilization of the NIH’s high-performance computing capabilities, are preferred.

Salary/Benefits

The current salary range is commensurate with experience and accomplishments.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae and complete bibliography, and the names of and contact information for three references to NCATSstemcellhiring@mail.nih.gov. The review of applications will begin immediately and will continue until the position is filled.

 

Stem Cell Scientist and Postdoctoral Positions, Division of Preclinical Innovation

National Institutes of Health
National Center for Advancing Translational Sciences
Division of Preclinical Innovation
Chemical Genomics Branch
Stem Cell Translation Laboratory
Rockville, Maryland

Description

NCATS, a major research component of the NIH, seeks applications from qualified candidates with expertise in developmental biology and human induced pluripotent stem cells (iPSCs) to fill stem cell scientist and postdoctoral positions in the Stem Cell Translation Laboratory (SCTL) within the Chemical Genomics Branch of the Center’s Division of Preclinical Innovation. The SCTL focuses on translating human pluripotent stem cells, such as iPSCs, into clinical applications and drug discovery by developing innovative technologies, methods and comprehensive multi-omics data sets through differentiation into relevant cell types in 2-D/3-D cell culture systems. Successful candidates will have a chance to develop their skills in a highly dynamic environment, embedded in a team of passionate scientists working on a wide range of projects related to translational stem cell biology. They will have a chance to interact with experienced bioinformaticians at NCATS, external service providers and collaborators at top academic institutions.

Core Responsibilities

The selected candidates will join a multidisciplinary team of innovative scientists with expertise in assay development, high-throughput and high-content screening, compound management, automation engineering, bioinformatics, medicinal chemistry and various “-omics” technologies. They will work in a highly creative environment, focusing on important aspects of human pluripotency and cellular differentiation using cutting-edge technologies (e.g., single-cell analysis, deep sequencing, robotic cell culture, high-throughput electrophysiology, genome editing). They will keep accurate and complete records of all scientific experiments according to established procedures and ensure that these records and raw data are properly retained. They also will draft technical reports, manuscripts and patent applications and present work internally and externally to consultants and collaborators as needed.

Qualifications

Each applicant must possess an advanced degree (M.D. and/or Ph.D.) in a relevant field. Exceptional candidates with master’s degrees and strong backgrounds in stem cell biology will be considered. Candidates with experience in drug discovery, cell and tissue engineering, cell signaling, or quantitative biology are encouraged to apply. The ideal candidates should be team players with high scientific standards and have the ability to work in an interactive, fast-paced environment. They must be self-motivated to learn new technologies and be familiar with the methods and concepts of stem cell biology and regenerative medicine.

Stipends/Benefits

Annual stipends are provided and are based on the NIH Postdoctoral Intramural Research Training Award scale; health insurance benefits are available. Fellows also are able to take part in Foundation for Advanced Education in the Sciences courses at the NIH.

How to Apply

Please submit a cover letter describing your interest in the position, a current curriculum vitae and complete bibliography, and the names of and contact information for three references to NCATSstemcellhiring@mail.nih.gov.

The review of applications will begin immediately and will continue until the position is filled.