U.S. Department of Health and Human ServicesHHS National Institutes of HealthNIH National Center for Advancing Translational SciencesNCATS
SCTL scientists are working on various projects to address efficiency, reproducibility, scalability, and other roadblocks in the translation of iPSCs into therapies.

The Induced Pluripotent Stem Cell (iPSC) Portal is a scientific repository provided by the Stem Cell Translation Laboratory (SCTL) at NIH’s National Center for Advancing Translational Sciences (NCATS). The iPSC Portal hosts rigorous protocols and searchable datasets generated by SCTL scientists to serve as a reference resource for validated iPSC growth and differentiation protocols, quality control, experimental workflows, data analysis pipelines, and more. Established technologies include large compound libraries, quantitative high-throughput and high-content screening, robotic automation of cell culture workflows, multi-scale assay development, 3-D bioprinting, next-generation sequencing, and integrated platforms to profile gene and protein expression and measure functional endpoints in standard cultures, as well as on the single-cell level.


Meet the current members of the SCTL and learn about projects underway in the lab.

Members from left to right, back row: Charles “Pepper” Bonney, Pinar Ormanoglu, Claire Malley, Ilyas Singec, Jaroslav Slamecka, Vukasin Jovanovic, Tao Deng.

Left to right, front row: Robin Yu Chen, Yeliz Gedik, Pei-Hsuan Chu, Seungmi Ryu, Carlos Tristan, Michael Iannotti,  Elena Barnaeva.

Photo: Daniel Soñé Photography, LLC


A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells

Yu Chen1,2, Carlos A. Tristan1,2, Lu Chen1, Vukasin M. Jovanovic1, Claire Malley1, Pei-Hsuan Chu1, Seungmi Ryu1, Tao Deng1, Pinar Ormanoglu1, Dingyin Tao1, Yuhong Fang1, Jaroslav Slamecka1, Hyenjong Hong1,…

Robotic High-Throughput Biomanufacturing and Functional Differentiation of Human Pluripotent Stem Cells

Carlos A. Tristan, Pinar Ormanoglu, Jaroslav Slamecka, Claire Malley, Pei-Hsuan Chu, Vukasin M. Jovanovic, Yeliz Gedik, Charles Bonney, Elena Barnaeva, John Braisted, Sunil K. Mallanna, Dorjbal Dorjsuren, Michael…


SCTL Scientists identify small-molecule cocktail to improve stem cell use in research and disease treatments
In a series of experiments, SCTL scientists used high-throughput screening to systematically test thousands of compounds and drugs…
See our new publication on bioRxiv
A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells Yu Chen, Carlos A.…