U.S. Department of Health and Human ServicesHHS National Institutes of HealthNIH National Center for Advancing Translational SciencesNCATS
SCTL scientists are working on various projects to address efficiency, reproducibility, scalability, and other roadblocks in the translation of iPSCs into therapies.

The Induced Pluripotent Stem Cell (iPSC) Portal is a scientific repository provided by the Stem Cell Translation Laboratory (SCTL) at NIH’s National Center for Advancing Translational Sciences (NCATS). The iPSC Portal hosts rigorous protocols and searchable datasets generated by SCTL scientists to serve as a reference resource for validated iPSC growth and differentiation protocols, quality control, experimental workflows, data analysis pipelines, and more. Established technologies include large compound libraries, quantitative high-throughput and high-content screening, robotic automation of cell culture workflows, multi-scale assay development, 3-D bioprinting, next-generation sequencing, and integrated platforms to profile gene and protein expression and measure functional endpoints in standard cultures, as well as on the single-cell level.


Meet the current members of the SCTL and learn about projects underway in the lab.

Members from left to right, back row: Charles “Pepper” Bonney, Pinar Ormanoglu, Claire Malley, Ilyas Singec, Jaroslav Slamecka, Vukasin Jovanovic, Tao Deng.

Left to right, front row: Robin Yu Chen, Yeliz Gedik, Pei-Hsuan Chu, Seungmi Ryu, Carlos Tristan, Michael Iannotti,  Elena Barnaeva.

Photo: Daniel Soñé Photography, LLC


Directed Differentiation of Human Pluripotent Stem Cells into Radial Glia and Astrocytes Bypasses Neurogenesis

Vukasin M. Jovanovic, Claire Malley, Carlos A. Tristan, Seungmi Ryu, Pei-Hsuan Chu, Elena Barnaeva, Pinar Ormanoglu, Jennifer Colon Mercado, Sam Michael, Michael E. Ward, Anton Simeonov, Ilyas Singeç…

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Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small Molecules

Seungmi Ryu, Pei-Hsuan Chu, Claire Malley, John Braisted, Pinar Ormanoglu, Ruili Huang, Misha Itkin, Zina Itkin, Paul Shinn, Carleen Klumpp-Thomas, Sam Michael, Carlos A. Tristan, Anton Simeonov, and…


SCTL Scientists identify small-molecule cocktail to improve stem cell use in research and disease treatments
In a series of experiments, SCTL scientists used high-throughput screening to systematically test thousands of compounds and drugs…
See our new publication on bioRxiv
A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells Yu Chen, Carlos A.…